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Testing Pleiotropy
作者:SM Lutz2017被引用次数:10 — [Zhang et al., 2014] This method, called Pleiotropy Estimation and Test- Bootstrap (PET-B), estimates the pleiotropy of two normally distributed ...
作者:DJ Schaid2016被引用次数:36 — Genetic pleiotropy is when a single gene influences more than one trait. ... A formal test of pleiotropy should assume a null hypothesis that one ...

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作者:DJ Schaid2016被引用次数:36 — The test for pleiotropy provides strong evidence that the signal of association was driven by a single phenotype. This is confirmed ...
作者:Z Yuan2020被引用次数:17 — In simulations, PMR-Egger provides calibrated type I error control for causal effect testing in the presence of horizontal pleiotropic ...
作者:S Hackinger2017被引用次数:62 — In the classical GWAS approach, the association of genetic variants across the entire genome with a single phenotype of interest is tested in a ...
作者:FJ Boehm2019被引用次数:4 — We extend the method of Jiang and Zeng (1995), for testing pleiotropy with a pair of traits, to the case of more than two alleles.
作者:D Ray2020被引用次数:7 — The underlying methods, however, are often designed to test the global null hypothesis that there is no association of a genetic variant with ...

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