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Cancer Drug Resistance is an open access journal, focusing on pharmacological aspects of drug resistance and its reversal, molecular mechanisms of drug ...
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by N Vasan2019Cited by 558Drug resistance continues to be the principal limiting factor to achieving cures in patients with cancer. The ...
by B Mansoori2017Cited by 627Cancer cells will become resistant to drugs by the mechanisms such as the inactivation of the drug, multi-drug resistance, cell death inhibition (apoptosis ...
ALL: Increased Akt expression; Regulation protein-1 and PI3K signaling; PTEN muta...
Disease: Drug resistance Mechanism and pathways interruption
AML: GSK-3b activity; adhesion and Wnt-pathway b-catenin expression; SHIP mutati...
Myeloproliferative disorders: JAK2
by G Housman2014Cited by 1651Many anticancer drugs require metabolic activation, and thus cancer cells can develop resistance through decreased drug activation. In patients with advanced ...
by RA Ward2020Cited by 45There is a wide range of mechanisms to which cancer cells are inherently resistant, or acquire resistance, to drug therapies. These mechanisms ...
May 10, 2021Cancer cells may develop the ability to rewire or reprogram themselves to become resistant to treatments that were previously effective.
Combining Cancer DrugsMolecular alterations that contribute to intrinsic or acquired treatment resistance include mutation of the drug's molecular target ...
by S Bhattacharya2021Cited by 5Drug resistance is a major impediment in cancer. Although it is generally thought that acquired drug resistance ...
One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. This is a very serious problem that ...
by H Zahreddine2013Cited by 544Resistance to drugs continues to be a major problem in oncology affecting the majority of cancer patients. Here we provide many examples of how ...

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