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4D5, affinity
by X Liu2015Cited by 357Lower affinity CART cells (4D5-5 and 4D5-3) were strongly reactive to tumors with amplified ErbB2 expression and exhibited undetectable or low reactivity to the ...
C1) and higher (fig. C2) CAR densities, respectively. Figures C3 and C4 describes the cytokine release for low-affinity 4D5-5 CAR-T (Kd = 1.12 µM) with lower ( ...
by D Ye1999Cited by 209A humanized anti-HER2 monoclonal antibody (mAb) 4D5 and a human-mouse ... affinity and activity (Stern and Kamps, 1988; Qian et al., 1994).
by B Salzer2020Cited by 24a Schematic of a conventional CAR (high-affinity CAR) typically ... we incorporated the hHER2-specific low-affinity scFv 4D5-5 (Kd of 1.1 ...
by S Kubetzko2006Cited by 147Using the p185HER-2 (HER-2)-specific scFv 4D5 as model system, we analyzed how ... Functional affinity of 4D5 miniantibodies on SK-OV-3 cells Binding ...
by J Jayaraman2020Cited by 30CAR-T cells using a lower-affinity 4D5 variant (KD ~ 1 μM) showed an ... While reducing affinity has been shown to improve CAR-T–cell ...
by AP Singh2020Cited by 25C2) CAR densities, respectively. Figures C3 and C4 describes the cytokine release for low-affinity 4D5-5 CAR-T (Kd = 1.12 µM) with lower (fig.
Similar to parent. 4D5-28Z construct (with a native Ab affinity of 0.3 nM), all CARs using lower affinity scFvs showed transgene decrease as well, which.
by RB Di Roberto2020Cited by 5(B) Representative flow cytometry plots of GFP expression in CAR T cells possessing a high-affinity anti-HER2. scFv domain (4D5) and ...
The optimal Ig concentration for an application varies by species and antibody affinity. For each product, the antibody titer must be optimized for every ...

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