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The first or priming step is achieved through the activation of the nuclear factor kappa B (NF-κB) pathway, leading to the upregulation of NLRP3 and pro-IL-1β proteins (4) and to changes in NLRP3 post-translational modifications (PTMs) such as ubiquitination (5) and phosphorylation (6) that licence NLRP3 and promote ...
2020年9月30日
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2016/09/23 Consistent with this transcriptional role in the priming step, macrophages constitutively expressing high levels of NLRP3 via a retroviral...
2019/02/12 Activation of NLRP3 inflammasome in macrophages requires two steps: priming and activation. The priming step (signal 1) is provided by...
To avoid excessive inflammatory response, activation of the NLRP3 inflammasome is tightly regulated and requires a two-step process. The first step is the...
NLRP3 Activation. Activation of the NLRP3 inflammasome in primary macrophages requires two distinct steps. First, NLRP3 must be primed (e.g., signal I)...
2019/02/20 The maturation and secretion of pro-caspase-1 and pro-IL-1β are critical steps for inflammasome activation (Franchi et al, 2009).
2016/02/23 In the first step of NLRP3 inflammasome activation, inflammatory stimuli activate the transcription factor nuclear factor κB (NF-κB),...
The NLRP3 inflammasome is activated in a 2-step process. First, NF-κB signaling is induced through PAMP- or DAMP-mediated activation of TLR4 or TNFR,...
2021/09/21 So, we first analyzed NLRP3 inflammasome activation in WT, ... and this may be an additional PP2A-sensitive step in the NLRP3 pathway (56).

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