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10 hours ago · Arginine in the treatment of cancer
Arginine metabolism and tumors Some researchers have exploited this cancer cell arginine requirement as an antineoplastic therapy to selectively starve tumors. Arginine deiminase (ADI), an arginine-metabolizing enzyme isolated from Mycoplasma, can inhibit tumor cell growth in culture and in animal tumor models.
Oct 1, 2004

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May 6, 2020 · Depriving cancer cells from arginine does not only have a cytotoxic effect but also induces cell cycle arrest in some types of cancer cells. Cell cycle analysis was done on the surviving population of ovarian and pancreatic cancer cells to examine the effect of arginine deprivation on the cell cycle.
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Certain cancers may be auxotrophic for a particular amino acid and amino acid deprivation is one method to treat these tumors. Arginine deprivation is a novel ... Abstract · INTRODUCTION · CLINICAL STUDIES WITH ...
In the following part, arginine depletion on cancer treatment is the highlight we will address. 2. Metabolism of arginine. 2.1. Endogenous synthesis of arginine.
While some studies confirm that Arg enhances tumor growth [7,8], others introduce it as an appropriate candidate for cancer treatment [[9], [10], [11]]. Therefore, ...
Aug 6, 2018 · Treating cultured human breast cancer cells with an NO donor (Box 1) resulted in the activation of the epidermal growth factor receptor (EGFR) ...
Nov 22, 2018 · Since then, numerous studies were initiated to treat arginine auxotrophic cancers and today, Mycoplasma sp.-derived PEG-formulated ADI is ...
Oct 26, 2017 · For years, depletion of arginine has been shown to be an effective and promising anti-cancer treatment in vitro and in vivo (;). By culturing cells ...
Mar 16, 2018 · The importance of arginine metabolism as a novel field of investigation includes that of arginine depletion retarding the growth of some cancers ( ...