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10 hours ago · 4-ethylpyrazole
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4-甲基吡唑 (Fomepizole)

藥物
4-甲基吡唑是一種用於治療甲醇或乙二醇中毒的藥。通常通過靜脈注射的方式給藥,可單獨使用,也可與血液透析同時使用。 常見不良反應包括頭痛、噁心、嗜睡和暈眩。孕婦使用該藥對胎兒的安全性未知。4-甲基吡唑抑制乙醇脫氫酶,減少甲醇和乙二醇轉變為毒性更強的代謝產物。 1997年,美國允許4-甲基吡唑作為藥物使用。 維基百科
分子式C4H6N2
密度990 kg/m³
ChEBI ID5141
PubChem CID3406
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Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning. It may be used alone or together with ... Medical use · Kinetics Trade names: Antizol, others Routes of administration: Intravenous Boiling point: 204 to 207 °C (399 to 405 °F) (at 97,3 kPa) CAS Number: 7554-65-6
Fomepizole (4-methylpyrazole) is a competitive ADH inhibitor. It is used to block metabolism of ethylene glycol and methanol to their toxic metabolites. It should be given when a known or suspected toxic ethylene glycol or methanol ingestion has occurred and the patient has metabolic acidosis and elevated osmolar gap.
Fomepizole; CAS Number: 7554-65-6; EC Number: 231-445-0; Synonym: 4- Methylpyrazole; Linear Formula: C4H6N2; find Sigma-Aldrich-M9888 MSDS, related ... Density: 0.993 g/mL at 25 °C (lit.) Storage temp: 2-8°C Bp: 99-100 °C/6 mmHg (lit.)
Irritant. Laboratory Chemical Safety Summary (LCSS) Datasheet. Molecular Formula, C4H6N2. Synonyms. 4-Methylpyrazole. fomepizole. 4-Methyl-1H- pyrazole.
4-Methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, may be useful for the treatment of methanol and ethylene glycol intoxications.
Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase.
Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes metabolism of ethylene glycol and methanol to toxic metabolites.
4-Methylpyrazole (4-MP) is another appealing possible pharmacological therapy for these disorders due to its known inhibition of the visual cycle in rodents, its ...
2015年5月29日 · A pyrazole derivative, 4-methylpyrazole (4-MP), has been used medically as an antidote for methanol and ethylene glycol poisoning in the clinic ...
2019年11月25日 · CYP2E1 inhibition using 4-methylpyrazole (4-MP) has been shown to prevent APAP-induced liver injury in mice and human hepatocytes.